EWSR1 and Ewing sarcoma: Inspection of individual genes of interest revealed that KDM5A and PHF2 each positively control the expression of Ets1 and MCAM (Figure 4A), genes belonging to a metastasis-promoting pathway recently identified in Ewing sarcoma by our group [21], and negatively regulated by EWS/Fli1 (Figure 4B and 4C).