Further examination of genes subject to positive regulatory control of KDM5A and PHF2, and negative regulatory control by EWS/Fli1, revealed a number of additional genes not previously investigated in Ewing sarcoma, but shown to promote metastatic properties in other cancers, including ITGA7, LOXL2, L1CAM, NRCAM, PLAU, FLNC, LAMB1 and LAMC1 (Figure 4A–4C). This evidence concerns the gene PLAU and Ewing sarcoma.