Notably, while EWS/Fli1 imposes positive regulatory control over some pro-metastatic genes and pathways (eg: EZH2 [8] and PPP1R1A [9]), multiple studies indicate that, on balance, EWS/Fli1 exerts a repressive effect on important metastatic properties in Ewing sarcoma. Here, EWSR1 is linked to Ewing sarcoma.