Surprisingly, reported tumor/metastatic suppressor pathways: ‘transcriptional regulation by RUNX3’, ‘death receptor signaling’, and ‘regulation of PTEN stability and activity’ were up-regulated in lymph node-231 cells and as such deserve further investigation as to the function of these pathways in normal lymph nodes/lymphocytes/hematopoiesis, and reticular cells. This evidence concerns the gene RUNX3 and neoplasm.