Through increasing phospho-GSK-3β (Ser9) expression to reduce Tau phosphorylation, AM404 enhanced HSPB1 and GRP78 (glucose-regulated protein, 78 kDa) expression, increased pro-aggregated Tau solubility, and promoted neurite outgrowth in ΔK280 TauRD AD cell model [34]. The gene discussed is HSPA5; the disease is Alzheimer disease.