It was further demonstrated that TGFβ-induced ANGPTL4 enhances the retention of cancer cells in the lungs, disrupted vascular endothelial cell–cell junctions, increased the permeability of the lung capillaries, and facilitated the trans-endothelial passage of tumor cells, thus promoted the critical steps of metastasis [46]. This evidence concerns the gene TGFB1 and neoplasm.