To further support the participation of CD11c+-expressing cells in scrapie pathogenesis, a study by Raymond et al. revealed that transient in vivo depletion of migratory CD11c+-expressing cells in Peyer’s patches, mesenteric lymph nodes and the spleens of mice before oral exposure to two scrapie agent strains, ME7 and 139A, blocked the accumulation of PrPSc in lymphoid tissues and significantly prolonged susceptibility to disease [50]. The gene discussed is ITGAX; the disease is scrapie.