At the completion of the study, we found that VRQ/ARQ and ARQ/ARQ sheep inoculated with CD11c+ B1 lymphocytes and CD68+ macrophages developed scrapie with detectable levels of PrPSc in the CNS and lymphoreticular system (LRS), while those inoculated with platelet-rich plasma did not develop disease. The gene discussed is ITGAX; the disease is scrapie.