F8 and hemophilia A: Patients with hemophilia A may require major surgery, including elective orthopedic interventions due to chronic hemophilic arthropathy that develops following recurrent joint bleeds.1, 2To provide hemostatic control and protect against an increased risk of blood loss during major surgery, patients require peri- and postoperative correction of their low or missing factor VIII (FVIII) level by administration of a FVIII product.