The molecular basis of these different stages appear to be linked to the presence of β-amyloid (Aβ) in senile plaques and cerebral amyloid angiopathy, as well as tau proteins (tau) in neurofibrillary tangles (Brettschneider, Del Tredici, Lee, & Trojanowski, 2015; Jack Jr. Here, MAPT is linked to cerebral amyloid angiopathy.