NOS2 and osteoporosis: A. rugosa leaf extract attenuates expression of iNOS and NO production in ROS 17/2.8 cells activated by a mixture of inflammatory cytokines including TNF-α and interleukin-1β and reduces the cellular toxicity induced by sodium nitroprusside, a nitric oxide donor, suggesting its beneficial role in NO-mediated conditions such as osteoporosis [40].