Apelin, a ligand of the G protein-coupled receptor APJ (57), which reduces oxidative stress and prevents cardiac hypertrophy in HF (58), stimulates proliferation of cancer cells in cholangiocarcinoma (CAA) (59), non-small cell lung cancer (NSCLC) (60), gastric cancer (61), prostate cancer (62), ovarian cancer (63), and oral squamous cell carcinoma (64). This evidence concerns the gene APLN and non-small cell lung carcinoma.