KRT4 and triple-A syndrome: At 1 week after AngII infusion, when inflammation and oxidative stress are prevalent and preceed the formation of AAA, we observed significant upregulation (>130%) of methylation of K4, K9, K27, K79 (H3K4me3, H3K9me2, H3K27me3, H3K79me1/me3), acetylation of K9, K18 (H3K9ac, H3K18ac) and phosphorylation of ser10 (H3ser10P), while there was significant downregulation (<70%) of H3K9me1, H3K36me1, and H3K56ac (Figures 3A,B).