At 2 weeks after AngII infusion, which represents the middle stage of AAA formation, mono- and try-methylation of K79 (H3K79me1/me3) and phosphorylation of ser28 (H3ser28P) was upregulated, whereas methylation (H3K4me2, H3K9me3, H3K36me1, H3K27me1, H3K27me3, H3K36me1) and acetylation (H3K9ac, H3ser10P, H3K9ac, H3K14ac, H3K56ac) were largely downregulated (Figures 3A,B). The gene discussed is AGT; the disease is triple-A syndrome.