IGF1 and myocardial ischemia: In addition, miRNA-208B-3P, miRNA-128-3P, and miRNA-320 are all related to myocardial ischemia and apoptosis, with down-regulation of miRNA-208B-3P inhibiting of myocardial injury caused by ischemia/reperfusion in rats (133), while inhibition of miRNA-128-3P protects myocardial cells from ischemia/reperfusion injury by upregulation of P70S6k1/P-P70S6k1 (134), and down-regulation of miRNA-320 inhibits apoptosis of myocardial cells and provides protection against myocardial ischemia and reperfusion injury by targeting IGF-1 (135).