NOS3 and myocardial ischemia: Li et al. (79) showed that KMUP-1 [7-[2-[4-(2-chlorophenyl) piperazinyl] ethyl]−1] activated e-NOS expression and restored the intracellular calcium flow by upregulating the NO/cGMP/MAPK signaling pathway, which inhibited the apoptosis induced by myocardial ischemia.