Therefore, the objectives of this study were to determine whether (a) GGT levels were further increased in male patients; (b) abnormalities of GGT activities were related to hemodynamic dysfunction and clinical characters; (c) male patients with BMPR2 mutation had higher GGT levels than those of females; (d) serum GGT could be a predictor for prognosis and clinical outcomes in male patients with IPAH. Here, BMPR2 is linked to idiopathic pulmonary arterial hypertension.