PLEKHF1 and coronary artery disorder: We identified the following genes from the light green module as significant DRAG candidates: RTKN, DCP1B, PDZD4, CACNA2D2, TSEN54, PVRIG, PLEKHF1, NKG7, ZAP70, NUDCD3, SLAMF6, CCDC107, NAG6, ZDHHC14, EOMES, VIL2, WDR54, DMAP1, and PMPCA. Their expression progressively increased in healthy control, DM and DMCHD (Figure 4A), the differential expression of these genes in three different groups healthy control, DM, DMCHD might be the reason which lead to DM patients with coronary heart disease, but whether this is the cause of this result needs further exploration.