We identified 19 genes in the light green module as DRAGs (RTKN, DCP1B, PDZD4, CACNA2D2, TSEN54, PVRIG, PLEKHF1, NKG7, ZAP70, NUDCD3, SLAMF6, CCDC107, NAG6, ZDHHC14, EOMES, VIL2, WDR54, DMAP1, and PMPCA), the differential expression of these genes in three different groups healthy control, DM, DMCHD might be the reason which lead to DM patients with coronary heart disease, but whether this is the cause of this result needs further exploration. The gene discussed is PLEKHF1; the disease is diabetes mellitus.