In fact, a link between accumulation of MGO and development of a epigenetic memory has been made by El-Osta et al. Overexpression of GLO1 prevented the persistent increase of p65 expression in endothelial cells following transient hyperglycemia, while GLO1 knockdown mice, displayed increased p65 expression in their endothelial cells even when normoglycemic (32). The gene discussed is GLO1; the disease is Hyperglycemia.