MiR-200a-3p accelerated cardiac hypertrophy by directly modulating WDR1 and simultaneously regulating PTEN/PI3K/AKT/CREB/WDR1 pathway (60), while the miR302-367 cluster was found to impair autophagy to worsen cardiac hypertrophy through silencing PTEN and consequently activating PI3K/AKT/mTOR pathway (59). The gene discussed is PTEN; the disease is cardiac hypertrophy.