WRN and malignant colon neoplasm: Further, protein interaction data of PAXX protein in HCT-116 colon cancer cell line from “Bioplex 2.0” database also revealed interaction of PAXX with Werner syndrome ATP-dependent helicase (WRN), an established mediator of NHEJ pathway, supporting the involvement of PAXX in NHEJ pathway in colon cancer (Figure 8K).