Interestingly, PAXX was also observed to interact with genes involved in glutathione metabolism, including glutathione peroxidase 1 and 7 (GPX1 and GPX7, respectively), which are primarily involved in protecting cells from oxidative stress, suggesting additional pro-tumor roles of PAXX in conferring therapeutic resistance to colon cancer cells. Here, GPX1 is linked to malignant colon neoplasm.