To assess the oncogenic pathways associated with PAXX expression in colon cancer, we performed gene set enrichment analysis (GSEA) for cancer hallmarks pathways using genes that exhibited significant correlations with PAXX. Among positively correlated pathways, PAXX expression exhibited the most significant correlation with oxidative phosphorylation (Figure 8A), besides other metabolic pathways including glycolysis (Figure 8F), fatty acid metabolism (Figure 8G), and adipogenesis (Figure 8H). This evidence concerns the gene PAXX and colonic neoplasm.