To determine the expression pattern of core NHEJ genes in colon cancer, we performed Oncomine analysis for XRCC6 (Ku70), XRCC5 (Ku80), PRKDC (DNA-PKcs), XRCC4 (XRCC4), LIG4 (DNA ligase 4), NHEJ1 (XLF), and PAXX (PAXX/XLS). The gene discussed is LIG4; the disease is malignant colon neoplasm.