PAXX and neoplasm: Consistent with the Oncomine analysis, comparison of all available normal (n = 41) and tumor tissues (n = 469) revealed overexpression of XRCC6, XRCC5, PRKDC, XRCC4, and PAXX in tumors compared to normal tissues, while LIG4 and NHEJ1 displayed lower expression in the tumor tissues (Figure 1A).