Consistent with the Oncomine analysis, comparison of all available normal (n = 41) and tumor tissues (n = 469) revealed overexpression of XRCC6, XRCC5, PRKDC, XRCC4, and PAXX in tumors compared to normal tissues, while LIG4 and NHEJ1 displayed lower expression in the tumor tissues (Figure 1A). Here, LIG4 is linked to neoplasm.