Notably, the preoperative PSA concentration, clinical tumor stage, and primary Gleason score were identified as significant predictors of lymph node metastasis, as were all evaluated CXC chemokine/receptors, with the exceptions of CXCR2 and CXCL8 (Table 3A). The gene discussed is CXCL8; the disease is metastatic malignant neoplasm in the lymph nodes.