In this study, the expression levels of ELR+ CXC chemokines/receptors (CXCL1, CXCL3, CXCL6, CXCR1, and CXCR2) increased in bone metastases of PC in the cytokine–cytokine receptor interaction pathway gene set. This evidence concerns the gene CXCL6 and pachyonychia congenita.