However, the identification of CXCL10 as an independent predictor of regional lymph node metastasis and the association of CXCL10/CXCR3 co-expression with postoperative recurrence, suggests involvement of the ELR− CXC chemokine/receptor axis in the mechanism of PC metastasis. Here, CXCL10 is linked to pachyonychia congenita.