Correlated with chromosomal aberrations such as gain 1q21, t (4:14), mutations in ATR and IRF4 genes; miR-199a-3p affects the multi-chemoresistance of OS via targeting AK4; overexpression correlates with osteolytic bone destruction in MM; overexpressed in BTZ-resistant MM cell lines. This evidence concerns the gene IRF4 and Miyoshi myopathy.