CircMYBL2 is significantly upregulated in AML patients with FLT3-ITD mutations and it increases the translational efficiency of FLT3 transcript, by facilitating binding of polypyrimidine tract binding protein 1 (PTBP1) to FLT3 transcript (Sun et al., 2019). Here, PTBP1 is linked to acute myeloid leukemia.