Upregulation of circ-PRMT5 were observed in NSCLC tissues and they were associated with larger tumors, lymph node metastasis, later clinical TNM stage, poor OS and PFS in NSCLC patients and is an independent prognostic factor for NSCLC patients (Wang Y. et al., 2019). The gene discussed is PRMT5; the disease is non-small cell lung carcinoma.