Recently, CRISPR Cas9 technology has been utilized to knockout SEL1L adaptor protein in HEK293 cell line, in order to rescue very low-density lipoprotein receptor (VLDLR) mutant protein responsible for Dysequilibrium syndrome (DES) (Ali et al., 2012). The gene discussed is LDLR; the disease is cerebellar ataxia, intellectual disability, and dysequilibrium.