Considering the surprising performance of deep learning technology in medical image analysis region (Wang et al., 2016; Liu et al., 2017; Li and Ping, 2018), especially generating synthetic medical images using generative adversarial networks (GAN) and its variants (Goodfellow et al., 2014; Hoffman et al., 2017; Nie et al., 2017; Frid-Adar et al., 2018a,b; Han et al., 2018; Kazeminia et al., 2018; Mahmood et al., 2018; Shin et al., 2018), generating synthetic Ki-67 pathology microscopy images from HE pathology microscopy images using GAN would be a good choice. This evidence concerns the gene MKI67 and hereditary elliptocytosis.