The FMR1 premutation carriers are at risk of developing Fragile X-associated tremor/ataxia syndrome (FXTAS) and Fragile X-associated primary ovarian insufficiency (FXPOI) in adulthood (Allingham-Hawkins et al., 1999; Hagerman et al., 2001), as well as other unspecific syndromes (Mila et al., 2018). Here, FMR1 is linked to premature ovarian failure 1.