We have previously reported that Trpv1 and Trpv3 mRNAs were significantly decreased, whereas Trpv2 and Trpv4 mRNAs were significantly increased in the white adipose tissue (WAT) of either db/db or diet-induced obesity (DIO) mice (Sun et al., 2017a). Here, TRPV2 is linked to obesity due to melanocortin 4 receptor deficiency.