Recent studies on BRCA2 have shown that pathogenic variants that confer high risk for breast and ovarian cancer completely abrogate BRCA2-mediated HR, whereas variants that result in a reduction of 50% in HR, i.e., hypomorphic variants, may only be associated with a moderate risk for breast cancer (Odds ratio ∼2.5) (Shimelis et al., 2017; Mesman et al., 2019). The gene discussed is BRCA2; the disease is breast carcinoma.