Nonetheless, the fact that roles other than in HR (i.e., in replication fork stability/recovery) for all three major breast cancer susceptibility genes (BRCA1, BRCA2 and PALB2) have been described (Schlacher et al., 2011; Murphy et al., 2014; Chaudhuri et al., 2016; Daza-Martin et al., 2019), complicates the interpretation of VUS in these genes and their association with cancer risk. This evidence concerns the gene BRCA2 and breast cancer.