Yet, considering that at a population level only ~50% of people with T2D meet the HbA1c target of ≤ 53 mmol·mol (69), and within 6y of starting oral hyperglycaemic agents, ~25% require exogenous insulin (70), evidence is based on cohorts that are not representative of the wider patient population. This evidence concerns the gene INS and type 2 diabetes mellitus.