Supplemental vitamin C may decrease the severity of obesity and its co-morbidities by regulating lipid accumulation, inhibiting lipolysis that reduces systematic FFA efflux, and glucocorticoid production, reducing ROS activity and interfering adipocyte macrophages, thus decrease pro-inflammatory adipokines (leptin) and cytokines (107). This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.