Activated AhRs initiates the production of inflammation factors (IL-1β, IL-6, and TNF-α), induces tissue factor (TF) and PAI-1 mediated thromboembolism (AhR-TF/PAI-1 pathway) (142), and lead multiple organ fibrosis via Cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1)/IL-22 signaling pathway with signal transducer and activator of transcription 3 (STAT3) (143). Here, SERPINE1 is linked to fibrosis.