In addition, the considerable genetic heterogeneity of the Brazilian population and the wide range of possible microenvironments may be highly advantageous for the study of genetic and environmental aspects associated with APOL1. These factors, along with Brazil's current critical situation in the face of the COVID-19 pandemic, make it the ideal country for conducting studies that assess the likely existence of a SARS-CoV-2-nephropathy. This evidence concerns the gene APOL1 and Nephropathy.