a) confirmed COVID-19 b) SaO2 <93%, or Pao2/Fio2 <300 mm Hg; c) pro-inflammatory and pro-thrombotic profile (at least 3 of the following): CRP > × 10 normal values; ferritin >1,000 ng/ml; D-dimer × 10 normal values; LDH × 2 the upper limits. Here, CRP is linked to COVID-19.