ACE and hypercalcemia disease: It has been clearly demonstrated that hypercalciuria and hypercalcemia are reliable negative prognostic factors, being associated with a chronic-persistent disease phenotype, high angiotensin-converting enzyme (ACE) levels, old age, hypergammaglobulinemia, and extrapulmonary sarcoid localizations (particularly in the spleen, bone and kidneys) (12–14).