Deficiencies in dynein and its regulators such as dynactin and LIS1 (Lissencephaly-1) cause devastating neurodegenerative diseases and brain developmental disorders (Wynshaw-Boris, 2007; Maday et al., 2014; Guedes-Dias and Holzbaur, 2019; Markus et al., 2020). Here, PAFAH1B1 is linked to classic lissencephaly.