SPARC and cancer: Secreted protein acidic and rich in cysteine (SPARC) encodes a cysteine-rich acidic matrix-associated protein, which is essential for extracellular matrix synthesis and epithelial–mesenchymal transition that promotes migration and invasion of many cancers (Sun et al., 2018; Jiang et al., 2019; López-Moncada et al., 2019).