Furthermore, AMN1 and ZP3 may be protective factors in osteosarcoma (HR: 1.26e−36 and 1.13e−07, respectively), whereas LIMS1, SAMD4A, and SPARC appear to be harmful factors in this setting (HR: 699.2, 167, and 298.7, respectively). Here, SPARC is linked to osteosarcoma.