Even though the role of Hakai in E-cadherin ubiquitination in physiological conditions remains unclear (Niño et al., 2019), it is intriguing that the expression of this ligase is gradually increased during the different stages of colon cancer progression, which is in line with its suggested role in E-cadherin modulation in EMT (Castosa et al., 2018). This evidence concerns the gene CDH1 and colonic neoplasm.