ACTR2 and cancer: RCP-driven endocytic recycling of α5β1 integrin enhances invasive migration of cancer cells by reprogramming the actin cytoskeleton to promote the formation of cell protrusions and actin-related protein 2/3 (Arp2/3) complex-independent cancer cell invasion in vivo (Jacquemet et al., 2013; Paul et al., 2015).