TMEM59 and Alzheimer disease: In the present study, we observed that TMEM59 protein levels were significantly elevated in 5xFAD mice during aging; and this is consistent with the previous reports of high TMEM59 expression levels and low DNA methylation in the TMEM59 promoter region in AD patients compared to controls (Bakulski et al., 2012; Guttula et al., 2012), strengthening the correlation between TMEM59 and AD.