To ascertain whether TMEM59 dysregulation influences AD pathology, we delivered lentivirus expressing either TMEM59 (Lenti-TMEM59, tagged with Flag) or EGFP as a control (Lenti-Control) into the mouse hippocampus bilaterally at 2 months of age (Figure 1A). The gene discussed is TMEM59; the disease is Alzheimer disease.