LAMP1 and Alzheimer disease: Many previous studies have demonstrated that LAMP1, a lysosomal marker for endo-lysosomal and autophagic vesicles, is enriched in dystrophic neurites and accumulates around Aβ plaques in AD mouse models (Condello et al., 2011; Gowrishankar et al., 2015; Yuan et al., 2016) as well as in AD patients (Terry et al., 1964; Barrachina et al., 2006; Hassiotis et al., 2018).