Transcription factor TCF4 (T-cell factor 4) is known to be indispensable for tumor initiation (Hrckulak et al., 2018) and TCF4/β-catenin transcriptional activity mediated by Wnt signaling was proposed to control upregulation of SLC6A14 in colon cancer. The gene discussed is SLC6A14; the disease is colonic neoplasm.