For example, tumor migration can be activated by the EMT process from the binding between VWC domain with TGFβ (Wendt et al., 2010; Zhu et al., 2015), and the angiogenesis from the binding between of CT domain with integrin αvβ3 (Wang L. H. et al., 2017). Here, TGFB1 is linked to neoplasm.