For example, CTGF expression can inhibit tumor growth by reducing VEGF mediated angiogenic effects through TSP1 domain (Inoki et al., 2002; Chang et al., 2006) and enhance angiogenesis and osteosarcoma through the binding between CT domain and integrin αvβ3 (Shimo et al., 2001; Wang L. H. et al., 2017). Here, CCN2 is linked to osteosarcoma.