YAP1 and cancer: This RhoA-dependent induction of cytoskeletal contractility is required for the nuclear translocation and activation of the transcriptional factor yes-associated protein 1 (YAP), a mechanotransducer that has cardinal roles in development, tissue homeostasis (Dupont et al., 2011), cancer (Calvo et al., 2013), and cardiovascular diseases (Wang et al., 2016).