This RhoA-dependent induction of cytoskeletal contractility is required for the nuclear translocation and activation of the transcriptional factor yes-associated protein 1 (YAP), a mechanotransducer that has cardinal roles in development, tissue homeostasis (Dupont et al., 2011), cancer (Calvo et al., 2013), and cardiovascular diseases (Wang et al., 2016). This evidence concerns the gene YAP1 and cardiovascular disorder.