In spite of this similarity, β-actin and γ-actin could play unique roles in cultured fibroblasts, epithelial, and cancer cells by participating in different molecular events during cell proliferation, differentiation, and motility (Bunnell et al., 2011; Lechuga et al., 2014; Dugina et al., 2015, 2018; Patrinostro et al., 2017; Malek et al., 2020). This evidence concerns the gene ACTB and cancer.