Since β-actin cKO mice and other mouse models with selective perturbation of the intestinal epithelial cytoskeleton (Su et al., 2009; Naydenov et al., 2016) possess two key common features, a leaky gut barrier in otherwise healthy animals and exaggerated mucosal inflammation during experimental colitis, these models provide strong support for the idea that leaky gut barrier could worsen the severity of gastrointestinal diseases in human patients. Here, ACTB is linked to colitis.