CASP3 and pancreatic neoplasm: In addition, irisin has been shown to suppress pancreatic cancer cell growth and proliferation (Liu et al., 2018), and to enhance doxorubicin-induced pancreatic cancer cell apoptosis through the upregulation of caspase-3 expression and the reduction of anti-apoptotic B-cell lymphoma 2 (Bcl-2) and Bcl-xL expression (Liu et al., 2019).