Our previous studies have demonstrated that hypoxia contributes to the growth and metastasis of HCC via regulating protein-coding genes and non-coding RNAs, such TUFT1 (Dou et al., 2019b), VASP (Liu et al., 2018), miR-1296 (Xu et al., 2017a), and RUNX1-IT1 (Sun et al., 2020). The gene discussed is RUNX1; the disease is hepatocellular carcinoma.