However, the activity and expression of SPCA1 were decreased during cerebral ischemia/reperfusion, and its ability to uptake intracellular Ca2+ was also impaired, leading to intracellular Ca2+ overload (Pavlíková et al., 2009; Li et al., 2015; Fan et al., 2016). This evidence concerns the gene ATP2C1 and Cerebral ischemia.