CASP3 and cardiac hypertrophy: Beginning at day 40, cardiomyocytes derived from KO line presented remarkably increased mRNA expression of fetal program, hypertrophy, hypertrophic signaling, fibrosis, calcium handling and apoptosis (CASP3, BAX) which has been identified to be closely related to cardiac hypertrophy (Figure 5A and Supplementary Figure S4A; Mosqueira et al., 2018).