Generally, Ca2 + entering the cardiomyocytes initially binds to calmodulin and then activates Ca2 +-dependent cascades in the form of Ca2 +-calmodulin complex, such as Ca2 +-calmodulin-CaMKII and Ca2 +-calmodulin-calcineurin pathways, which are major signal mediators of cardiac hypertrophy and remodeling (Lehman et al., 2018). The gene discussed is CAMK2G; the disease is cardiac hypertrophy.