Although PRCP was originally purified from lysosomes, it is constitutively expressed on the surface of the cell membrane and plays versatile roles in cell proliferation, autophagy, oxidative stress, inflammation, vascular homeostasis, and various diseases such as hypertension, obesity, diabetes, and thrombosis by metabolizing peptides including Ang II, Ang III, prekallikrein, and alpha-melanocyte-stimulating hormone (α-MSH) (Yang et al., 1968; Adams et al., 2011; Chajkowski et al., 2011; Maier et al., 2017). This evidence concerns the gene AGT and obesity due to melanocortin 4 receptor deficiency.