GRM5 and Cognitive impairment: The mGlu5 KO mice demonstrate impaired prepulse inhibition (PPI) (Brody and Geyer, 2004; Burrows et al., 2015), baseline hyperactivity and a hypersensitivity to MK-801-induced hyperlocomotion (Lipina et al., 2007; Gray et al., 2009), impaired circadian process (Aguilar et al., 2020), clinically relevant cognitive deficits on touchscreen tasks (Zeleznikow-Johnston et al., 2018) and thus excellent face validity as a preclinical model of SZ.