AKT1 and intervertebral disk degenerative disorder: Recently, research demonstrated that the compression treatment on NP cells could lead to the activation of the NF-κB pathway, MAPK pathway, and the deactivation of the PI3K/Akt pathway (Jiang et al., 2018; Li et al., 2018; Glaeser et al., 2020; Huang et al., 2020), which provided new insights into the association between mechanical stress and IDD.