CAV1 and cancer: The discovery of new communication patterns between cancer and stromal cells, in which Cav-1 seems to be an important key note for both sides (Sotgia et al., 2012), prompted a new paradigm for prognosis of certain cancer types, based on evaluation of Cav-1 in stromal cells (Witkiewicz et al., 2009; Zhao et al., 2013).