DCN and neoplasm: Moreover, COL6A3, DCN, and LUM, which were upregulated after the WNT pulse here, are all typical markers for the switch to a mesenchymal phenotype in lens epithelial and tumor cells (Saika et al., 2004; Chandler et al., 2007; Mathias et al., 2010; Clarke et al., 2017; Huang et al., 2018; Meng et al., 2018).