NARS1 and microcephaly: Wang L. et al. (2020) have conducted related verifications with whole-exome sequencing and uncovered microcephaly-related mutations of NARS1 in more than 5,000 people with neurodevelopmental disorders. They have generated cortical brain organoids with NARS1 mutations and found that patient-derived organoids display a smaller size, decreased proliferation, and cell cycle defects of RGs (Wang L. et al., 2020).