SERPINA1 and COVID-19: In conclusion, due to the known roles of AAT and its current use in clinics (Chapman et al., 2009, 2015; Forssmann et al., 2010; Lewis, 2012; Griese and Scheuch, 2016; Marcondes et al., 2016; Brantly et al., 2018; Campos et al., 2019), AAT treatment may represent a safe drug with potential activity in treating COVID-19 affected patients.