Therefore, even though AAT levels are correctly risen in COVID-19 patients, AAT augmentation may be useful to modulate the production and activity of key pro-inflammatory cytokines, while preserving the production of the anti-inflammatory cytokine IL-10 (Guttman et al., 2015); (iii) AATD is a largely under-recognized condition (De Serres et al., 2003). This evidence concerns the gene IL10 and COVID-19.