In the current study, when we explored the signaling pathways of DEGs between COVID-19 and normal samples, we found that these DEGs were mainly enriched in “response to virus,” “lymphocyte activation,” “antiviral mechanism by IFN-stimulated genes” and “regulation of inflammatory response,” which were related to the physiological processes of inflammation and immunity, demonstrating that genes with altered expression in patients infected with SARS-CoV-2 were associated with the regulation of inflammation and immune response. Here, IFNA1 is linked to COVID-19.