SERPINB5 and neoplasm: Experimentally, maspin showed tumor suppressive activities of blocking cell growth, invasion, and metastasis (Narayan and Twining, 2010; Berardi et al., 2013); inhibiting angiogenesis (Cher et al., 2003); sensitizing tumor cell to drug-induced apoptosis (Liu et al., 2004); and arresting cell cycle progress (Li et al., 2006) in mammary tumors.