KRT8 and posterior cortical atrophy: Since PCa cells are more prone to lose their epithelial phenotype in favor of a more mesenchymal phenotype, which is a trigger for aggressiveness and metastasis (Cheaito et al., 2019), we employed immunofluorescent staining of tumor AUB-PrC cells using CK8 (luminal epithelial cell marker) and vimentin (VIM; mesenchymal cell marker), showing evidence of VIM + expression (Supplementary Figure S2B).